ARHGEF5

Protein-coding gene in the species Homo sapiens
ARHGEF5
Identifiers
AliasesARHGEF5, GEF5, P60, TIM, TIM1, Rho guanine nucleotide exchange factor 5
External IDsOMIM: 600888; MGI: 1858952; HomoloGene: 66300; GeneCards: ARHGEF5; OMA:ARHGEF5 - orthologs
Gene location (Human)
Chromosome 7 (human)
Chr.Chromosome 7 (human)[1]
Chromosome 7 (human)
Genomic location for ARHGEF5
Genomic location for ARHGEF5
Band7q35Start144,355,288 bp[1]
End144,380,632 bp[1]
Gene location (Mouse)
Chromosome 6 (mouse)
Chr.Chromosome 6 (mouse)[2]
Chromosome 6 (mouse)
Genomic location for ARHGEF5
Genomic location for ARHGEF5
Band6|6 B2.1Start43,242,516 bp[2]
End43,266,254 bp[2]
RNA expression pattern
Bgee
HumanMouse (ortholog)
Top expressed in
  • skin of leg

  • skin of abdomen

  • mucosa of transverse colon

  • left lobe of thyroid gland

  • right lobe of thyroid gland

  • duodenum

  • minor salivary glands

  • human kidney

  • body of pancreas

  • prostate
Top expressed in
  • skin of external ear

  • epithelium of stomach

  • duodenum

  • lip

  • jejunum

  • large intestine

  • colon

  • pyloric antrum

  • mucous cell of stomach

  • left colon
More reference expression data
BioGPS
More reference expression data
Gene ontology
Molecular function
  • GTP binding
  • protein binding
  • lipid binding
  • guanyl-nucleotide exchange factor activity
Cellular component
  • cytoplasm
  • cell projection
  • plasma membrane
  • nucleoplasm
  • cell junction
  • podosome
  • nucleus
  • cell periphery
  • cytosol
Biological process
  • intracellular signal transduction
  • regulation of actin cytoskeleton organization
  • positive regulation of JUN kinase activity
  • regulation of GTPase activity
  • positive regulation of DNA-binding transcription factor activity
  • positive regulation of podosome assembly
  • myeloid dendritic cell chemotaxis
  • positive regulation of GTPase activity
  • positive regulation of protein import
  • regulation of ERK1 and ERK2 cascade
  • regulation of Rho protein signal transduction
  • regulation of cytoskeleton organization
  • actin cytoskeleton organization
  • positive regulation of stress fiber assembly
  • positive regulation of apoptotic process
  • regulation of small GTPase mediated signal transduction
  • G protein-coupled receptor signaling pathway
Sources:Amigo / QuickGO
Orthologs
SpeciesHumanMouse
Entrez

7984

54324

Ensembl

ENSG00000050327

ENSMUSG00000033542

UniProt

Q12774

E9Q7D5

RefSeq (mRNA)

NM_001002861
NM_005435

NM_133674

RefSeq (protein)

NP_005426

NP_598435

Location (UCSC)Chr 7: 144.36 – 144.38 MbChr 6: 43.24 – 43.27 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Rho guanine nucleotide exchange factor 5 is a protein that in humans is encoded by the ARHGEF5 gene.[5][6][7]

Rho GTPases play a fundamental role in numerous cellular processes initiated by extracellular stimuli that work through G protein-coupled receptors. The encoded protein may form a complex with G proteins and stimulate Rho-dependent signals. This protein may be involved in the control of cytoskeletal organization.[7]

References

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000050327 – Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000033542 – Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ Chan AM, McGovern ES, Catalano G, Fleming TP, Miki T (Apr 1994). "Expression cDNA cloning of a novel oncogene with sequence similarity to regulators of small GTP-binding proteins". Oncogene. 9 (4): 1057–63. PMID 8134109.
  6. ^ Takai S, Chan AM, Yamada K, Miki T (Oct 1995). "Assignment of the human TIM proto-oncogene to 7q33→q35". Cancer Genet Cytogenet. 83 (1): 87–9. doi:10.1016/S0165-4608(95)00017-8. PMID 7656213.
  7. ^ a b "Entrez Gene: ARHGEF5 Rho guanine nucleotide exchange factor (GEF) 5".

External links

Further reading

  • Snyder JT, Worthylake DK, Rossman KL, et al. (2002). "Structural basis for the selective activation of Rho GTPases by Dbl exchange factors". Nat. Struct. Biol. 9 (6): 468–75. doi:10.1038/nsb796. PMID 12006984. S2CID 13161854.
  • Wistow G, Bernstein SL, Wyatt MK, et al. (2002). "Expressed sequence tag analysis of adult human lens for the NEIBank Project: over 2000 non-redundant transcripts, novel genes and splice variants". Mol. Vis. 8: 171–84. PMID 12107413.
  • Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
  • Hillier LW, Fulton RS, Fulton LA, et al. (2003). "The DNA sequence of human chromosome 7". Nature. 424 (6945): 157–64. Bibcode:2003Natur.424..157H. doi:10.1038/nature01782. PMID 12853948.
  • Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
  • Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
  • Umetsu DT, Dekruyff RH (2005). "Regulation of tolerance in the respiratory tract: TIM-1, hygiene, and the environment". Ann. N. Y. Acad. Sci. 1029 (1): 88–93. doi:10.1196/annals.1309.012. PMID 15681748. S2CID 38149688.
  • Benzinger A, Muster N, Koch HB, et al. (2005). "Targeted proteomic analysis of 14-3-3 sigma, a p53 effector commonly silenced in cancer". Mol. Cell. Proteomics. 4 (6): 785–95. doi:10.1074/mcp.M500021-MCP200. PMID 15778465.
  • Zhang Y, Wolf-Yadlin A, Ross PL, et al. (2005). "Time-resolved mass spectrometry of tyrosine phosphorylation sites in the epidermal growth factor receptor signaling network reveals dynamic modules". Mol. Cell. Proteomics. 4 (9): 1240–50. doi:10.1074/mcp.M500089-MCP200. PMID 15951569.


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