Histidine methyl ester
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Other names Methyl L-histidinate, HME | |
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3D model (JSmol) |
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Beilstein Reference | 957974 |
ChEBI |
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ChEMBL |
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ChemSpider |
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ECHA InfoCard | 100.014.645 |
EC Number |
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PubChem CID |
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CompTox Dashboard (EPA) |
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InChI
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Properties | |
Chemical formula | C7H11N3O2 |
Molar mass | 169.184 g·mol−1 |
Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa). Infobox references |
Chemical compound
Histidine methyl ester (HME) is an irreversible histidine decarboxylase inhibitor.[1][2][3] It is the methyl ester of histidine.
See also
- Histidine decarboxylase
- α-Fluoromethylhistidine
References
- ^ Lane, Roger S; Manning, James M; Snell, Esmond E (2002). "Histidine decarboxylase of lactobacillus 30a: inactivation and active-site labeling by L-histidine methyl ester". Biochemistry. 15 (19): 4180–5. doi:10.1021/bi00664a008. PMID 963031.
- ^ Alston, Theodore A; Abeles, Robert H (2002). "Reaction of Lactobacillus histidine decarboxylase with L-histidine methyl ester". Biochemistry. 26 (13): 4082–5. doi:10.1021/bi00387a051. PMID 3651438.
- ^ Komori, H; Nitta, Y; Ueno, H; Higuchi, Y (2012). "Structural Study Reveals That Ser-354 Determines Substrate Specificity on Human Histidine Decarboxylase". The Journal of Biological Chemistry. 287 (34): 29175–83. doi:10.1074/jbc.M112.381897. PMC 3436558. PMID 22767596.
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Monoamine metabolism modulators
(dopamine, epinephrine,
norepinephrine)
PAHTooltip Phenylalanine hydroxylase |
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THTooltip Tyrosine hydroxylase |
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DBHTooltip Dopamine beta-monooxygenase |
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PNMTTooltip Phenylethanolamine N-methyltransferase |
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COMTTooltip Catechol-O-methyl transferase |
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(serotonin, melatonin)
TPHTooltip Tryptophan hydroxylase |
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AANATTooltip Serotonin N-acetyl transferase |
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ASMTTooltip Acetylserotonin O-methyltransferase |
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HDCTooltip Histidine decarboxylase |
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HNMTTooltip Histamine N-methyltransferase |
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DAOTooltip Diamine oxidase |
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See also: Receptor/signaling modulators • Adrenergics • Dopaminergics • Melatonergics • Serotonergics • Monoamine reuptake inhibitors • Monoamine releasing agents • Monoamine neurotoxins
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