SPRY1

Protein-coding gene in the species Homo sapiens
SPRY1
Identifiers
AliasesSPRY1, hsprouty RTK signaling antagonist 1
External IDsOMIM: 602465; MGI: 1345139; HomoloGene: 4266; GeneCards: SPRY1; OMA:SPRY1 - orthologs
Gene location (Human)
Chromosome 4 (human)
Chr.Chromosome 4 (human)[1]
Chromosome 4 (human)
Genomic location for SPRY1
Genomic location for SPRY1
Band4q28.1Start123,396,795 bp[1]
End123,403,760 bp[1]
Gene location (Mouse)
Chromosome 3 (mouse)
Chr.Chromosome 3 (mouse)[2]
Chromosome 3 (mouse)
Genomic location for SPRY1
Genomic location for SPRY1
Band3|3 BStart37,694,096 bp[2]
End37,698,747 bp[2]
RNA expression pattern
Bgee
HumanMouse (ortholog)
Top expressed in
  • pericardium

  • vena cava

  • gallbladder

  • parietal pleura

  • epithelium of colon

  • subcutaneous adipose tissue

  • canal of the cervix

  • skin of leg

  • left uterine tube

  • left lobe of thyroid gland
Top expressed in
  • secondary oocyte

  • tail of embryo

  • lip

  • primary oocyte

  • lung

  • esophagus

  • quadriceps femoris muscle

  • right kidney

  • zone of skin

  • adrenal gland
More reference expression data
BioGPS
More reference expression data
Gene ontology
Molecular function
  • protein binding
Cellular component
  • Golgi apparatus
  • membrane
  • plasma membrane
  • nucleoplasm
  • cytoplasm
  • cytosol
Biological process
  • ureteric bud development
  • negative regulation of neurotrophin TRK receptor signaling pathway
  • negative regulation of epidermal growth factor receptor signaling pathway
  • organ induction
  • bud elongation involved in lung branching
  • negative regulation of Ras protein signal transduction
  • multicellular organism development
  • negative regulation of fibroblast growth factor receptor signaling pathway
  • negative regulation of GTPase activity
  • regulation of signal transduction
  • negative regulation of MAP kinase activity
  • establishment of mitotic spindle orientation
  • metanephros development
  • negative regulation of cell population proliferation
  • negative regulation of ERK1 and ERK2 cascade
  • epithelial to mesenchymal transition involved in cardiac fibroblast development
Sources:Amigo / QuickGO
Orthologs
SpeciesHumanMouse
Entrez

10252

24063

Ensembl

ENSG00000164056

ENSMUSG00000037211

UniProt

O43609

Q9QXV9

RefSeq (mRNA)

NM_001258038
NM_001258039
NM_005841
NM_199327
NM_001375410

NM_011896
NM_001305440
NM_001305441
NM_001305442

RefSeq (protein)

NP_001244967
NP_001244968
NP_005832
NP_955359
NP_001362339

NP_001292369
NP_001292370
NP_001292371
NP_036026

Location (UCSC)Chr 4: 123.4 – 123.4 MbChr 3: 37.69 – 37.7 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Protein sprouty homolog 1 is a protein that in humans is encoded by the SPRY1 gene.[5][6][7]


See also

References

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000164056 – Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000037211 – Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ Hacohen N, Kramer S, Sutherland D, Hiromi Y, Krasnow MA (January 1998). "sprouty encodes a novel antagonist of FGF signaling that patterns apical branching of the Drosophila airways". Cell. 92 (2): 253–63. doi:10.1016/S0092-8674(00)80919-8. PMID 9458049. S2CID 498977.
  6. ^ Haglund K, Schmidt MH, Wong ES, Guy GR, Dikic I (July 2005). "Sprouty2 acts at the Cbl/CIN85 interface to inhibit epidermal growth factor receptor downregulation". EMBO Reports. 6 (7): 635–41. doi:10.1038/sj.embor.7400453. PMC 1369112. PMID 15962011.
  7. ^ "Entrez Gene: SPRY1 sprouty homolog 1, antagonist of FGF signaling (Drosophila)".

Further reading

  • Lim J, Wong ES, Ong SH, Yusoff P, Low BC, Guy GR (October 2000). "Sprouty proteins are targeted to membrane ruffles upon growth factor receptor tyrosine kinase activation. Identification of a novel translocation domain". The Journal of Biological Chemistry. 275 (42): 32837–45. doi:10.1074/jbc.M002156200. PMID 10887178.
  • Egan JE, Hall AB, Yatsula BA, Bar-Sagi D (April 2002). "The bimodal regulation of epidermal growth factor signaling by human Sprouty proteins". Proceedings of the National Academy of Sciences of the United States of America. 99 (9): 6041–6. Bibcode:2002PNAS...99.6041E. doi:10.1073/pnas.052090899. PMC 122898. PMID 11983899.
  • Hanafusa H, Torii S, Yasunaga T, Nishida E (November 2002). "Sprouty1 and Sprouty2 provide a control mechanism for the Ras/MAPK signalling pathway". Nature Cell Biology. 4 (11): 850–8. doi:10.1038/ncb867. PMID 12402043. S2CID 31064800.
  • Di Y, Li J, Zhang Y, He X, Lu H, Xu D, et al. (June 2003). "HCC-associated protein HCAP1, a variant of GEMIN4, interacts with zinc-finger proteins". Journal of Biochemistry. 133 (6): 713–8. doi:10.1093/jb/mvg091. PMID 12869526.
  • Wang L, Ji C, Wu H, Xu J, Wu Q, Dai J, et al. (November 2003). "Identification and expression analysis of a novel splice variant of human Sprouty1 gene". International Journal of Molecular Medicine. 12 (5): 783–7. doi:10.3892/ijmm.12.5.783. PMID 14533010.
  • Anteby EY, Natanson-Yaron S, Greenfield C, Goldman-Wohl D, Haimov-Kochman R, Holzer H, Yagel S (July 2005). "Human placental Hofbauer cells express sprouty proteins: a possible modulating mechanism of villous branching". Placenta. 26 (6): 476–83. doi:10.1016/j.placenta.2004.08.008. PMID 15950061.
  • Cabrita MA, Jäggi F, Widjaja SP, Christofori G (September 2006). "A functional interaction between sprouty proteins and caveolin-1". The Journal of Biological Chemistry. 281 (39): 29201–12. doi:10.1074/jbc.M603921200. PMID 16877379.
  • Fritzsche S, Kenzelmann M, Hoffmann MJ, Müller M, Engers R, Gröne HJ, Schulz WA (September 2006). "Concomitant down-regulation of SPRY1 and SPRY2 in prostate carcinoma". Endocrine-Related Cancer. 13 (3): 839–49. doi:10.1677/erc.1.01190. PMID 16954433.
  • Schaaf G, Hamdi M, Zwijnenburg D, Lakeman A, Geerts D, Versteeg R, Kool M (January 2010). "Silencing of SPRY1 triggers complete regression of rhabdomyosarcoma tumors carrying a mutated RAS gene". Cancer Research. 70 (2): 762–71. doi:10.1158/0008-5472.CAN-09-2532. PMID 20068162.
  • Charles NJ, Huebert RC, Lee S, Adhikari N, Polster S, Rider JE, et al. (September 2010). "Targeted Sprouty1 overexpression in cardiac myocytes does not alter myocardial remodeling or function". Molecular and Cellular Biochemistry. 342 (1–2): 57–62. doi:10.1007/s11010-010-0468-8. PMC 2923832. PMID 20461448.

External links

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