SYT5

Protein-coding gene in the species Homo sapiens
SYT5
Identifiers
AliasesSYT5, synaptotagmin 5
External IDsOMIM: 600782; MGI: 1926368; HomoloGene: 55722; GeneCards: SYT5; OMA:SYT5 - orthologs
Gene location (Human)
Chromosome 19 (human)
Chr.Chromosome 19 (human)[1]
Chromosome 19 (human)
Genomic location for SYT5
Genomic location for SYT5
Band19q13.42|11pStart55,171,196 bp[1]
End55,180,289 bp[1]
Gene location (Mouse)
Chromosome 7 (mouse)
Chr.Chromosome 7 (mouse)[2]
Chromosome 7 (mouse)
Genomic location for SYT5
Genomic location for SYT5
Band7|7 A1Start4,542,764 bp[2]
End4,550,540 bp[2]
RNA expression pattern
Bgee
HumanMouse (ortholog)
Top expressed in
  • prefrontal cortex

  • right frontal lobe

  • cingulate gyrus

  • anterior cingulate cortex

  • nucleus accumbens

  • caudate nucleus

  • dorsolateral prefrontal cortex

  • Brodmann area 9

  • putamen

  • Brodmann area 10
Top expressed in
  • superior frontal gyrus

  • primary visual cortex

  • entorhinal cortex

  • dentate gyrus of hippocampal formation granule cell

  • perirhinal cortex

  • CA3 field

  • tongue

  • anterior amygdaloid area

  • ventromedial nucleus

  • lateral septal nucleus
More reference expression data
BioGPS


More reference expression data
Gene ontology
Molecular function
  • clathrin binding
  • metal ion binding
  • protein heterodimerization activity
  • calcium-dependent phospholipid binding
  • syntaxin binding
  • SNARE binding
  • phosphatidylinositol-4,5-bisphosphate binding
  • phosphatidylserine binding
  • calcium ion binding
Cellular component
  • integral component of membrane
  • endosome
  • membrane
  • synapse
  • synaptic vesicle membrane
  • cell junction
  • neuronal cell body
  • recycling endosome membrane
  • perinuclear region of cytoplasm
  • neuron projection
  • dense core granule
  • cytoplasmic vesicle
  • plasma membrane
  • proximal neuron projection
  • integral component of neuronal dense core vesicle membrane
  • axon
  • exocytic vesicle
Biological process
  • synaptic vesicle endocytosis
  • chemical synaptic transmission
  • vesicle fusion
  • regulation of calcium ion-dependent exocytosis
  • calcium ion-regulated exocytosis of neurotransmitter
  • regulation of dopamine secretion
  • synaptic vesicle exocytosis
  • vesicle-mediated transport
  • calcium-ion regulated exocytosis
  • cellular response to calcium ion
Sources:Amigo / QuickGO
Orthologs
SpeciesHumanMouse
Entrez

6861

53420

Ensembl

ENSG00000129990

ENSMUSG00000004961

UniProt

O00445

Q9R0N5

RefSeq (mRNA)

NM_001297774
NM_003180

NM_016908
NM_001360421
NM_001360422

RefSeq (protein)

NP_001284703
NP_003171

NP_001347350
NP_001347351

Location (UCSC)Chr 19: 55.17 – 55.18 MbChr 7: 4.54 – 4.55 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Synaptotagmin-5 is a protein that in humans is encoded by the SYT5 gene.[5][6]


References

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000129990 – Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000004961 – Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ Craxton M, Olsen A, Goedert M (Jul 1997). "Human synaptotagmin V (SYT5): sequence, genomic structure, and chromosomal location". Genomics. 42 (1): 165–9. doi:10.1006/geno.1997.4722. PMID 9177789.
  6. ^ "Entrez Gene: SYT5 synaptotagmin V".

Further reading

  • Hudson AW, Birnbaum MJ (1995). "Identification of a nonneuronal isoform of synaptotagmin". Proc. Natl. Acad. Sci. U.S.A. 92 (13): 5895–9. Bibcode:1995PNAS...92.5895H. doi:10.1073/pnas.92.13.5895. PMC 41608. PMID 7597049.
  • Perin MS (1996). "Mirror image motifs mediate the interaction of the COOH terminus of multiple synaptotagmins with the neurexins and calmodulin". Biochemistry. 35 (43): 13808–16. doi:10.1021/bi960853x. PMID 8901523.
  • Fukuda M, Kanno E, Mikoshiba K (1999). "Conserved N-terminal cysteine motif is essential for homo- and heterodimer formation of synaptotagmins III, V, VI, and X." J. Biol. Chem. 274 (44): 31421–7. doi:10.1074/jbc.274.44.31421. PMID 10531343.
  • Craxton M, Goedert M (1999). "Alternative splicing of synaptotagmins involving transmembrane exon skipping". FEBS Lett. 460 (3): 417–22. doi:10.1016/S0014-5793(99)01382-4. PMID 10556508. S2CID 19207631.
  • Mizutani A, Fukuda M, Ibata K, et al. (2000). "SYNCRIP, a cytoplasmic counterpart of heterogeneous nuclear ribonucleoprotein R, interacts with ubiquitous synaptotagmin isoforms". J. Biol. Chem. 275 (13): 9823–31. doi:10.1074/jbc.275.13.9823. PMID 10734137.
  • Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
  • Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
  • Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
  • Sreenath AS, Kumar KR, Reddy GV, et al. (2005). "Evidence for the association of synaptotagmin with glutathione S-transferases: implications for a novel function in human breast cancer". Clin. Biochem. 38 (5): 436–43. doi:10.1016/j.clinbiochem.2005.01.009. PMID 15820774.
  • Kimura K, Wakamatsu A, Suzuki Y, et al. (2006). "Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes". Genome Res. 16 (1): 55–65. doi:10.1101/gr.4039406. PMC 1356129. PMID 16344560.
  • v
  • t
  • e
Synaptic vesicle
SNARE
Q-SNARE
R-SNARE
Synaptotagmin
Other
COPICOPIIRME/Clathrin
CaveolaeOther/ungrouped
Vesicle formation
Adaptor protein complex 1:
Adaptor protein complex 2:
Adaptor protein complex 3:
Adaptor protein complex 4:
BLOC-1:
BLOC-2:
BLOC-3:
Coats:
Small GTPase
Other
See also vesicular transport protein disorders


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