Aromatase

CYP19A1
Struktur yang tersedia
PDBPencarian Ortolog: PDBe RCSB
Daftar kode id PDB

3EQM, 3S79, 3S7S, 4GL5, 4GL7, 4KQ8

Pengidentifikasi
AliasCYP19A1, ARO, ARO1, CPV1, CYAR, CYP19, CYPXIX, P-450AROM, cytochrome P450 family 19 subfamily A member 1
ID eksternalOMIM: 107910 MGI: 88587 HomoloGene: 30955 GeneCards: CYP19A1
Lokasi gen (Tikus)
Kromosom 9 (tikus)
Kr.Kromosom 9 (tikus)[1]
Kromosom 9 (tikus)
Lokasi genom untuk CYP19A1
Lokasi genom untuk CYP19A1
Pita9 A5.3|9 29.49 cMAwal54,073,221 bp[1]
Akhir54,175,394 bp[1]
Pola ekspresi RNA
Referensi data ekspresi selengkapnya
Ontologi gen
Fungsi molekuler• iron ion binding
• oxygen binding
• metal ion binding
• monooxygenase activity
• heme binding
• GO:0050602 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen
• electron transfer activity
• oxidoreductase activity
• aromatase activity
• oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen
• steroid hydroxylase activity
Komponen seluler• endoplasmic reticulum membrane
• Retikulum endoplasma
• membran
• komponen integral membran
Proses biologis• estrogen biosynthetic process
• androgen metabolic process
• negative regulation of chronic inflammatory response
• prostate gland growth
• sterol metabolic process
• negative regulation of macrophage chemotaxis
• steroid biosynthetic process
• female gonad development
• female genitalia development
• perkembangan payudara
• uterus development
• testosterone biosynthetic process
• androgen catabolic process
• positive regulation of estradiol secretion
• Rantai transpor elektron
Sumber:Amigo / QuickGO
Ortolog
SpesiesManusiaTikus
Entrez

1588

13075

Ensembl

ENSG00000137869

ENSMUSG00000032274

UniProt

P11511

P28649

RefSeq (mRNA)
NM_000103
NM_001347248
NM_001347249
NM_001347250
NM_001347251

NM_001347252
NM_001347253
NM_001347254
NM_001347255
NM_001347256
NM_031226

NM_007810
NM_001348171
NM_001348172
NM_001348173

RefSeq (protein)
NP_000094
NP_001334177
NP_001334178
NP_001334179
NP_001334180

NP_001334181
NP_001334182
NP_001334183
NP_001334184
NP_001334185
NP_112503

NP_001335100
NP_001335101
NP_001335102
NP_031836

Lokasi (UCSC)n/aChr 9: 54.07 – 54.18 Mb
Pencarian PubMed[2][3]
Wikidata
Lihat/Sunting ManusiaLihat/Sunting Tikus

Aromatase, juga disebutestrogen synthetase atau estrogen synthase, adalah sebuah enzim yang bertanggung jawab untuk langkah penting dalam biosintesis dari estrogen. Enzim tersebut berkode CYP19A1, sebuah anggopta dari keluarga besar sitokrome P450 (EC 1.14.14.1), yang bersifat monooksigenase yang memicu banyak reaksi yang terjadi pada steroidogenesis. Biasanya, aromatase bertanggung jawab untuk aromatisasi androgen menjadi estrogen.

Referensi

  1. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000032274 - Ensembl, May 2017
  2. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine. 
  3. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine. 

Bacaan tambahan

  • Attar E, Bulun SE (May 2006). "Aromatase inhibitors: the next generation of therapeutics for endometriosis?". Fertility and Sterility. 85 (5): 1307–18. doi:10.1016/j.fertnstert.2005.09.064. PMID 16647373. 
  • Chen S (August 1998). "Aromatase and breast cancer". Frontiers in Bioscience. 3 (4): d922–33. doi:10.2741/A333. PMID 9696881. 
  • Strobel HW, Thompson CM, Antonovic L (June 2001). "Cytochromes P450 in brain: function and significance". Current Drug Metabolism. 2 (2): 199–214. doi:10.2174/1389200013338577. PMID 11469726. 
  • Simpson ER, Clyne C, Rubin G, Boon WC, Robertson K, Britt K, Speed C, Jones M (2002). "Aromatase--a brief overview". Annual Review of Physiology. 64: 93–127. doi:10.1146/annurev.physiol.64.081601.142703. PMID 11826265. 
  • Bulun SE, Yang S, Fang Z, Gurates B, Tamura M, Zhou J, Sebastian S (December 2001). "Role of aromatase in endometrial disease". The Journal of Steroid Biochemistry and Molecular Biology. 79 (1–5): 19–25. doi:10.1016/S0960-0760(01)00134-0. PMID 11850203.  Parameter |s2cid= yang tidak diketahui akan diabaikan (bantuan)
  • Balthazart J, Baillien M, Ball GF (December 2001). "Phosphorylation processes mediate rapid changes of brain aromatase activity". The Journal of Steroid Biochemistry and Molecular Biology. 79 (1–5): 261–77. doi:10.1016/S0960-0760(01)00143-1. PMID 11850233.  Parameter |s2cid= yang tidak diketahui akan diabaikan (bantuan)
  • Richards JA, Petrel TA, Brueggemeier RW (February 2002). "Signaling pathways regulating aromatase and cyclooxygenases in normal and malignant breast cells". The Journal of Steroid Biochemistry and Molecular Biology. 80 (2): 203–12. doi:10.1016/S0960-0760(01)00187-X. PMID 11897504.  Parameter |s2cid= yang tidak diketahui akan diabaikan (bantuan)
  • Balthazart J, Baillien M, Ball GF (May 2002). "Interactions between aromatase (estrogen synthase) and dopamine in the control of male sexual behavior in quail". Comparative Biochemistry and Physiology. Part B, Biochemistry & Molecular Biology. 132 (1): 37–55. doi:10.1016/S1096-4959(01)00531-0. PMID 11997208. 
  • Meinhardt U, Mullis PE (2002). "The aromatase cytochrome P-450 and its clinical impact". Hormone Research. 57 (5–6): 145–52. doi:10.1159/000058374. PMID 12053085.  Parameter |s2cid= yang tidak diketahui akan diabaikan (bantuan)
  • Carreau S, Bourguiba S, Lambard S, Galeraud-Denis I, Genissel C, Levallet J (July 2002). "Reproductive system: aromatase and estrogens". Molecular and Cellular Endocrinology. 193 (1–2): 137–43. doi:10.1016/S0303-7207(02)00107-7. PMID 12161013.  Parameter |s2cid= yang tidak diketahui akan diabaikan (bantuan)
  • Meinhardt U, Mullis PE (August 2002). "The essential role of the aromatase/p450arom". Seminars in Reproductive Medicine. 20 (3): 277–84. doi:10.1055/s-2002-35374. PMID 12428207. 
  • Carreau S, Bourguiba S, Lambard S, Galeraud-Denis I (2003). "[Testicular aromatase]". Journal de la Société de Biologie. 196 (3): 241–4. doi:10.1051/jbio/2002196030241. PMID 12462076. 
  • Carani C, Fabbi M, Zirilli L, Sgarbi I (2003). "[Estrogen resistance and aromatase deficiency in humans]". Journal de la Société de Biologie. 196 (3): 245–8. doi:10.1051/jbio/2002196030245. PMID 12462077. 
  • Kragie L (August 2002). "Aromatase in primate pregnancy: a review". Endocrine Research. 28 (3): 121–8. doi:10.1081/ERC-120015041. PMID 12489562.  Parameter |s2cid= yang tidak diketahui akan diabaikan (bantuan)
  • Simpson ER (July 2000). "Biology of aromatase in the mammary gland". Journal of Mammary Gland Biology and Neoplasia. 5 (3): 251–8. doi:10.1023/A:1009590626450. PMID 14973387.  Parameter |s2cid= yang tidak diketahui akan diabaikan (bantuan)
  • Bulun SE, Takayama K, Suzuki T, Sasano H, Yilmaz B, Sebastian S (February 2004). "Organization of the human aromatase p450 (CYP19) gene". Seminars in Reproductive Medicine. 22 (1): 5–9. doi:10.1055/s-2004-823022. PMID 15083376. 
  • Simpson ER (February 2004). "Aromatase: biologic relevance of tissue-specific expression". Seminars in Reproductive Medicine. 22 (1): 11–23. doi:10.1055/s-2004-823023. PMID 15083377. 
  • Bulun SE, Fang Z, Imir G, Gurates B, Tamura M, Yilmaz B, Langoi D, Amin S, Yang S, Deb S (February 2004). "Aromatase and endometriosis". Seminars in Reproductive Medicine. 22 (1): 45–50. doi:10.1055/s-2004-823026. PMID 15083380. 
  • Shozu M, Murakami K, Inoue M (February 2004). "Aromatase and leiomyoma of the uterus". Seminars in Reproductive Medicine. 22 (1): 51–60. doi:10.1055/s-2004-823027. PMID 15083381. 
  • Chen S, Ye J, Kijima I, Kinoshita Y, Zhou D (May 2005). "Positive and negative transcriptional regulation of aromatase expression in human breast cancer tissue". The Journal of Steroid Biochemistry and Molecular Biology. 95 (1–5): 17–23. doi:10.1016/j.jsbmb.2005.04.002. PMID 15955695.  Parameter |s2cid= yang tidak diketahui akan diabaikan (bantuan)
  • Lambard S, Silandre D, Delalande C, Denis-Galeraud I, Bourguiba S, Carreau S (May 2005). "Aromatase in testis: expression and role in male reproduction". The Journal of Steroid Biochemistry and Molecular Biology. 95 (1–5): 63–9. doi:10.1016/j.jsbmb.2005.04.020. PMID 16019206.  Parameter |s2cid= yang tidak diketahui akan diabaikan (bantuan)
  • Bulun SE, Imir G, Utsunomiya H, Thung S, Gurates B, Tamura M, Lin Z (May 2005). "Aromatase in endometriosis and uterine leiomyomata". The Journal of Steroid Biochemistry and Molecular Biology. 95 (1–5): 57–62. doi:10.1016/j.jsbmb.2005.04.012. PMID 16024248.  Parameter |s2cid= yang tidak diketahui akan diabaikan (bantuan)
  • Lambard S, Carreau S (October 2005). "Aromatase and oestrogens in human male germ cells". International Journal of Andrology. 28 (5): 254–9. doi:10.1111/j.1365-2605.2005.00546.x alt=Dapat diakses gratis. PMID 16128984. 
  • Ellem SJ, Risbridger GP (March 2006). "Aromatase and prostate cancer". Minerva Endocrinologica. 31 (1): 1–12. PMID 16498360. 
  • Brueggemeier RW, Díaz-Cruz ES (March 2006). "Relationship between aromatase and cyclooxygenases in breast cancer: potential for new therapeutic approaches". Minerva Endocrinologica. 31 (1): 13–26. PMID 16498361. 
  • Jongen VH, Hollema H, Van Der Zee AG, Heineman MJ (March 2006). "Aromatase in the context of breast and endometrial cancer. A review". Minerva Endocrinologica. 31 (1): 47–60. PMID 16498363. 
  • Hiltunen M, Iivonen S, Soininen H (March 2006). "Aromatase enzyme and Alzheimer's disease". Minerva Endocrinologica. 31 (1): 61–73. PMID 16498364. 

Pranala luar

  • "U.S. study of gay sheep may shed light on sexuality", via WikiNews, 15 August 2005.
  • Lokasi genom CYP19A1 manusia dan halaman rincian gen CYP19A1 dalam UCSC Genome Browser.
  • Templat:PDBe-KB2