TCF7L2 |
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Наявні структури |
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PDB | Пошук ортологів: PDBe RCSB | Список кодів PDB | 2GL7, 1JDH, 1JPW | | |
Ідентифікатори |
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Символи | TCF7L2, TCF-4, TCF4, transcription factor 7 like 2 |
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Зовнішні ІД | OMIM: 602228 MGI: 1202879 HomoloGene: 7564 GeneCards: TCF7L2 |
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Пов'язані генетичні захворювання |
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цукровий діабет 2-го типу, біполярний афективний розлад, рак молочної залози, ішемічна хвороба серця, метаболічні захворювання, колоректальний рак[1] |
Онтологія гена |
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Молекулярна функція | • sequence-specific DNA binding • DNA binding • beta-catenin binding • gamma-catenin binding • GO:0001131, GO:0001151, GO:0001130, GO:0001204 DNA-binding transcription factor activity • transcription factor binding • GO:0000980 RNA polymerase II cis-regulatory region sequence-specific DNA binding • GO:0001948, GO:0016582 protein binding • armadillo repeat domain binding • protein kinase binding • GO:0001200, GO:0001133, GO:0001201 DNA-binding transcription factor activity, RNA polymerase II-specific • chromatin binding |
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Клітинна компонента | • beta-catenin-TCF7L2 complex • PML body • нуклеоплазма • protein-DNA complex • клітинне ядро • transcription regulator complex |
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Біологічний процес | • positive regulation of heparan sulfate proteoglycan biosynthetic process • positive regulation of protein kinase B signaling • GO:0009373 regulation of transcription, DNA-templated • glucose homeostasis • GO:0044324, GO:0003256, GO:1901213, GO:0046019, GO:0046020, GO:1900094, GO:0061216, GO:0060994, GO:1902064, GO:0003258, GO:0072212 regulation of transcription by RNA polymerase II • response to glucose • Wnt signaling pathway • regulation of smooth muscle cell proliferation • negative regulation of DNA-binding transcription factor activity • canonical Wnt signaling pathway involved in positive regulation of epithelial to mesenchymal transition • transcription, DNA-templated • positive regulation of protein export from nucleus • maintenance of DNA repeat elements • blood vessel development • myoblast fate commitment • canonical Wnt signaling pathway • pancreas development • positive regulation of protein binding • regulation of hormone metabolic process • проліферація • GO:0045996 negative regulation of transcription, DNA-templated • fat cell differentiation • negative regulation of canonical Wnt signaling pathway • beta-catenin-TCF complex assembly • Wnt signaling pathway, calcium modulating pathway • positive regulation of insulin secretion • GO:1901227 negative regulation of transcription by RNA polymerase II • GO:0003257, GO:0010735, GO:1901228, GO:1900622, GO:1904488 positive regulation of transcription by RNA polymerase II • negative regulation of type B pancreatic cell apoptotic process • negative regulation of extrinsic apoptotic signaling pathway • positive regulation of epithelial cell proliferation |
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Джерела:Amigo / QuickGO | |
Шаблон експресії |
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Більше даних |
Ортологи |
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Види | Людина | Миша |
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Entrez | | |
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Ensembl | | |
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UniProt | | |
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RefSeq (мРНК) | NM_001146274 NM_001146283 NM_001146284 NM_001146285 NM_001146286
| NM_001198525 NM_001198526 NM_001198527 NM_001198528 NM_001198529 NM_001198530 NM_001198531 NM_030756 NM_001349870 NM_001349871 NM_001363501 NM_001367943 |
| NM_001142918 NM_001142919 NM_001142920 NM_001142921 NM_001142922
| NM_001142923 NM_001142924 NM_009333 NM_001331135 NM_001331136 NM_001331137 NM_001331138 NM_001331139 NM_001331140 NM_001331141 NM_001331142 NM_001331143 NM_001331144 NM_001331145 NM_001331146 NM_001331147 NM_001331148 NM_001331149 NM_001331150 |
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RefSeq (білок) | NP_001139746 NP_001139755 NP_001139756 NP_001139757 NP_001139758
| NP_001185454 NP_001185455 NP_001185456 NP_001185457 NP_001185458 NP_001185459 NP_001185460 NP_110383 NP_001336799 NP_001336800 NP_001350430 NP_001354872 NP_001139757.1 |
| NP_001136390 NP_001136391 NP_001136392 NP_001136393 NP_001136394
| NP_001136395 NP_001136396 NP_001318064 NP_001318065 NP_001318066 NP_001318067 NP_001318068 NP_001318069 NP_001318070 NP_001318071 NP_001318072 NP_001318073 NP_001318074 NP_001318075 NP_001318076 NP_001318077 NP_001318078 NP_001318079 NP_033359 |
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Локус (UCSC) | Хр. 10: 112.95 – 113.17 Mb | Хр. 19: 55.73 – 55.92 Mb |
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PubMed search | [2] | [3] |
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Вікідані |
Див./Ред. для людей | Див./Ред. для мишей |
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